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Vascular Disease Prevention (Discontinued) The Effects of Prostaglandin E-1 in Patients with Intermittent ClaudicationĬardiovascular & Hematological Disorders-Drug Targets Ryanodine Receptor Patents Recent Progress in Graphene Derivatives/Metal Oxides Binary Nanocompositesīased Chemi-resistive Sensors for Disease Diagnosis by BreathĬurrent Analytical Chemistry Recent Applications of Doebner, Doebner-von Miller and Knoevenagel-Doebner Reactions in Organic SynthesesĬurrent Organic Synthesis C-Reactive Protein and Atherosclerosis: An Update Here, we have focused on the generation of new non-Ig binding proteins and singleĭomain antibody manipulation, with a glimpse of their applications. Robust folding, high solubility, and small size motivate their employment as a tool for biology and applied Very few of these scaffolds have successfully passed clinical trials, their remarkable properties such as Engineered protein scaffoldsĬan now be directed against therapeutic targets to treat cancer and immunological disorders. ![]() A combination of protein engineeringĪnd display technologies has been used to manipulate non-human antibodies for humanizationĪnd stabilization purposes or even the generation of new binding proteins. Specific binding proteins to supplement monoclonal antibodies. Keywords: Antibody, non-immunoglobulin, scaffold, protein binders, protein engineering, phage display.Ībstract: In recent years, extensive attention has been given to the generation of new classes of ligand. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz,Iran. ![]() Mohammadi, Manoochehr Makvandi, Morteza Mamouei, Mohammad Rahmati*, Hesam Dehghani and David W. Title:Recent Advances in the Scaffold Engineering of Protein BindersĪuthor(s): Mohammad K.B.
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